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(If you’d like to learn more on your own, see “History and overviews of hormone therapy.”) Not all doctors agree on when to use hormone therapy, or how to administer it.Indeed, this is an area that requires a physician to exercise as much art as science in clinical practice.For example, one small but often-cited study, published in 1999 in the found that 77% of men who had prostate cancer with lymph node metastases and chose to undergo hormone therapy were still alive and had no recurrent disease roughly seven years later, as compared with only 18% of men who decided to forgo hormone treatment until the cancer spread to bones or lungs. Although we don’t understand this phenomenon completely, animal studies suggest that a dose of radiation is more effective at killing cancer cells when given in the setting of androgen deprivation.A more recent analysis by the same group of researchers found that these trends held up over time (see Table 1). Short-Term Androgen Deprivation and Radiotherapy for Locally Advanced Prostate Cancer: Results from the Trans-Tasman Radiation Oncology Group 96.01 Randomised Controlled Trial. One leading theory about why this occurs is that the combination of radiation therapy and hormone therapy somehow activates the immune system, so that immune system cells attack and kill cancer cells.It explains when to consider hormone therapy, what your options are in terms of drugs or combinations of drugs, and what you should know about side effects.Finally, it explores several controversies currently being debated by medical experts, and where I stand on these issues.

In adolescent boys, androgens not only trigger sexual development, but also contribute to a deeper voice, a beard, and increased muscle strength and bone mass.You should also be aware that side effects can be daunting, although most men tolerate treatment reasonably well (see “Side effects of hormone therapy”).The most common use of hormone therapy today is to treat men whose prostate cancer has metastasized to other parts of the body.In fact, one of my patients has now been on some type of hormone therapy for nearly 16 years.Once reserved solely as a treatment for metastatic prostate cancer, hormone therapy is now also used in a variety of other ways.

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